Lilly drug chosen for Alzheimer's prevention study


Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.


The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.


Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.


"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.


She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.


In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.


Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.


About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.


___


Online:


Alzheimer's info: http://www.alzheimers.gov


Alzheimer's Association: http://www.alz.org


___


Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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Te'o Denies Involvement in Girlfriend Hoax













Notre Dame star linebacker Manti Te'o told ESPN that he "never, not ever" was involved in creating the hoax that had him touting what turned out to be a fictional girlfriend, "Lennay Kekua."


"When they hear the facts, they'll know," Te'o told ESPN's Jeremy Schaap in his first interview since the story broke. "They'll know that there is no way that I could be a part of this."


"I wasn't faking it," he said during a 2 1/2-hour interview, according to ESPN.com.


Te'o said he only learned for sure this week that he had been duped. On Wednesday, he received a Twitter message, allegedly from a man named Ronaiah Tuiasosopo, apologizing for the hoax, Te'o told Schaap.


The sports website Deadspin, which first revealed the hoax this week, has reported that Tuiasosopo, a 22-year-old of Samoan descent who lives in Antelope Valley, Calif., asked a woman he knew for her photo and that photo became the face of Kekua's Twitter account.


Te'o told Schaap that Tuiasosopo was represented to him as Kekua's cousin.


"I hope he learns," Te'o said of Tuiasosopo, according to coverage of the interview on ESPN.com. "I hope he understands what he's done. I don't wish an ill thing to somebody. I just hope he learns. I think embarrassment is big enough."


Click Here for a Who's Who in the Manti Te'o Case






AP Photo/ESPN Images, Ryan Jones











Manti Te'o Hoax: Was He Duped or Did He Know? Watch Video









Manti Te'o Hoax: Notre Dame Star Allegedly Scammed Watch Video









Tale of Notre Dame Football Star's Girlfriend and Her Death an Alleged Hoax Watch Video





Te'o admitted to a few mistakes in his own conduct, including telling his father he met Kekua in Hawaii even though his attempt to meet her actually failed. Later retellings of that tale led to inconsistencies in media reports, Te'o said, adding that he never actually met Kekua in person.


Te'o added that he feared people would think it was crazy for him to be involved with someone that he never met, so, "I kind of tailored my stories to have people think that, yeah, he met her before she passed away."


The relationship got started on Facebook during his freshman year, Te'o said.


"My relationship with Lennay wasn't a four-year relationship," Te'o said, according to ESPN.com. "There were blocks and times and periods in which we would talk and then it would end."


He showed Schaap Facebook correspondence indicating that other people knew of Kekua -- though Te'o now believes they, too, were tricked.


The relationship became more intense, Te'o said, after he received a call that Kekua was in a coma following a car accident involving a drunk driver on April 28.


Soon, Te'o and Kekua became inseparable over the phone, he said, continuing their phone conversations through her recovery from the accident, and then during her alleged battle against leukemia.


Even so, Te'o never tried to visit Kekua at her hospital in California.


"It never really crossed my mind," he said, according to ESPN.com. "I don't know. I was in school."


But the communication between the two was intense. They even had ritual where they discussed scripture every day, Te'o said. His parents also participated via text message, and Te'o showed Schaap some of the texts.


On Sept. 12, a phone caller claiming to be Kekua's relative told Te'o that Kekua had died of leukemia, Te'o said. However, on Dec. 6, Te'o said he got a call allegedly from Kekua saying she was alive. He said he was utterly confused and did not know what to believe.


ESPN's 2 1/2-hour interview was conducted in Bradenton, Fla., with Te'o's lawyer present but without video cameras. Schaap said Te'o was composed, comfortable and in command, and that he said he didn't want to go on camera to keep the setting intimate and avoid a big production.


According to ABC News interviews and published reports, Te'o received phone calls, text messages and letters before every football game from his "girlfriend." He was in contact with her family, including a twin brother, a second brother, sister and parents. He called often to check in with them, just as he did with his own family. And "Kekua" kept in contact with Te'o's friends and family, and teammates spoke to her on the phone.






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Sixty foreigners still caught in Sahara hostage crisis


ALGIERS (Reuters) - About 60 foreigners were still being held hostage or missing inside a gas plant on Friday after Algerian forces stormed the desert complex to free hundreds of captives taken by Islamist militants, who threatened to attack other energy installations.


The attack, which plunged capitals around the world into crisis mode, is a serious escalation of unrest in northwestern Africa, where French forces have been in Mali since last week fighting an Islamist takeover of Timbuktu and other towns.


"We are still dealing with a fluid and dangerous situation where a part of the terrorist threat has been eliminated in one part of the site, but there still remains a threat in another part," British Prime Minister David Cameron told his parliament.


A local Algerian source said 60 foreigners were still in the facility and some were being held hostage, but it was unclear how many and how many might be in hiding elsewhere in the sprawling compound. It was also not known whether some might have been killed and the bodies not found.


Those still unaccounted for included 10 from Japan, eight Norwegians and a number of Britons put by Cameron at "less than 30". Washington has said a number of Americans were among the hostages, without giving details, and the local source said a U.S. aircraft landed nearby on Friday.


As Western leaders clamored for news of their nationals, several expressed anger they had not been consulted by the Algerian government about its decision to storm the facility.


Algeria's state news agency said earlier more than half of 132 foreign hostages were freed and that the army had rescued 650 hostages, 573 of whom were Algerians.


"(The army) is still trying to achieve a ‘peaceful outcome' before neutralizing the terrorist group that is holed up in the (facility) and freeing a group of hostages that is still being held," it said, quoting a security source.


Thirty hostages, including several Westerners, were killed during Thursday's assault, the source said, along with at least 18 of their captors, who said they had taken the site as retaliation for French intervention against Islamists in neighboring Mali.


(Additional reporting by Ali Abdelatti in Cairo, Eamonn Mallie in Belfast, Gwladys Fouche in Oslo, Mohammed Abbas in London and Padraic Halpin and Conor Humprhies in Dublin; Writing by Philippa Fletcher; Editing by Alastair Macdonald)



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Japan's Abe condemns civilians' deaths in Algerian crisis






JAKARTA: Japanese Prime Minister Shinzo Abe has condemned the deaths of civilians in the Algerian hostage crisis.

He has also called on the Algerian government to prioritize the safety of hostages.

Mr Abe was speaking at a joint news conference in Jakarta after his meeting with Indonesian President Susilo Bambang Yudhoyono.

During their talks, both leaders agreed to strengthen their strategic partnership in political, security and economic relations.

Japan is involved in a maritime dispute with China over a group of islands in the East China Sea - a dispute that Mr Abe said should be resolved legally.

Mr Yudhoyono added that an open-sea policy should be enforced by law, and not by might.

He said: "All of us in Asia want to see a region that is stable, safe and peaceful. Therefore if there is a problem in the South China Sea or East Asia or anywhere in Asia, the solution should be peaceful, refrain from applying immediate military force and it must refer to international law. That is Indonesia's stance."

Prime Minister Abe's visit to Jakarta comes a day after the city was inundated with floodwaters. He expressed his sympathy towards the suffering of the flood victims in Greater Jakarta and vowed to help to restore and reconstruct damaged infrastructure.

Mr Abe also reaffirmed Japan's support for the development of Indonesia's railways, ports and sewage system, including the construction of the Cilamaya seaport and Jakarta's MRT.

- CNA/xq



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Lalu Prasad reveals Delhi gang-rape victim's name, demands death for rapists

KOLKATA: Rashtriya Janata Dal (RJD) chief Lalu Prasad while demanding death punishment for the perpetrators of the Delhi gang-rape and murder, mentioned the name of the victim on Friday.

"I went to meet the family of the victim in Ballia (Uttar Pradesh) and the father related how the young girl was subjected to barbarism. He revealed his daughter's name to me," said Lalu before mentioning the name of the victim to the audience.

"So long as a rape victim is alive you cannot mention her name, but in this case she is no more," added Prasad while addressing an interactive programme on women's empowerment organized by the FICCI Ladies Organization here.

Union law minister Ashwani Kumar this month had opined that the law was not in favour of revealing the identity of the victim.

Citing examples of Arab countries where criminals are stoned to death, Lalu Prasad demanded the culprits should be hanged and called for stronger laws and stringent punishment for rape and other crimes against women.

"Our party has always been advocating for punishment for rapists and in the next session of parliament we will put pressure on the government to amend the respective laws and provide death for rape," he said.

"If Raavan can be killed for abducting Sita, then why can't these inhumans be hanged. Unless there are stringent punishments we cannot prevent crime against women," Lalu Prasad said.

He also called for stirring up a nationwide mass movement to make the people aware about women rights.

A 23-year-old trainee physiotherapist was brutally raped by six men in a moving bus in south Delhi on December 16. She died on December 29 in a Singapore hospital where she was airlifted for specialized treatment.

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Food service vulnerable to food allergy lawsuits


WASHINGTON (AP) — People with severe food allergies have a new tool in their attempt to find menus that fit their diet: federal disabilities law. And that could leave schools, restaurants and anyplace else that serves food more vulnerable to legal challenges over food sensitivities.


A settlement stemming from a lack of gluten-free foods available to students at a Massachusetts university could serve as a precedent for people with other allergies or conditions, including peanut sensitivities or diabetes. Institutions and businesses subject to the Americans With Disabilities Act could be open to lawsuits if they fail to honor requests for accommodations by people with food allergies.


Colleges and universities are especially vulnerable because they know their students and often require them to eat on campus, Eve Hill of the Justice Department's civil rights division says. But a restaurant also could be liable if it blatantly ignored a customer's request for certain foods and caused that person to become ill, though that case might be harder to argue if the customer had just walked in off the street, Hill says.


The settlement with Lesley University, reached last month but drawing little attention, will require the Cambridge, Mass., institution to serve gluten-free foods and make other accommodations for students who have celiac disease. At least one student complained to the federal government after the school would not exempt the student from a meal plan even though the student couldn't eat the food.


"All colleges should heed this settlement and take steps to make accommodations," says Alice Bast, president and founder of the National Foundation for Celiac Awareness. "To our community this is definitely a precedent."


People who suffer from celiac disease don't absorb nutrients well and can get sick from the gluten found in wheat, rye and barley. The illness, which affects around 2 million Americans, causes abdominal pain, bloating and diarrhea, and people who have it can suffer weight loss, fatigue, rashes and other problems. Celiac is a diagnosed illness that is more severe than gluten sensitivity, which some people self-diagnose.


Ten years ago, most people had never heard of celiac disease. But awareness has exploded in recent years, for reasons that aren't entirely clear. Some researchers say it was under-diagnosed, others say it's because people eat more processed wheat products like pastas and baked goods than in past decades, and those items use types of wheat that have a higher gluten content.


Gluten-free diets have expanded beyond those with celiac disease. Millions of people are buying gluten-free foods because they say they make them feel better, even if they don't have a wheat allergy. Americans were expected to spend $7 billion on gluten-free foods last year.


With so many people suddenly concerned with gluten content, colleges and universities have had to make accommodations. Some will allow students to be exempted from meal plans, while others will work with students individually. They may need to do even more now as the federal government is watching.


"These kids don't want to be isolated," Bast says. "Part of the college experience is being social. If you can't even eat in the school cafeteria then you are missing out on a big part of college life."


Under the Justice Department agreement, Lesley University says it will not only provide gluten-free options in its dining hall but also allow students to pre-order, provide a dedicated space for storage and preparation to avoid cross-contamination, train staff about food allergies and pay a $50,000 cash settlement to the affected students.


"We are not saying what the general meal plan has to serve or not," Hill says. "We are saying that when a college has a mandatory meal plan they have to be prepared to make reasonable modifications to that meal plan to accommodate students with disabilities."


The agreement says that food allergies may constitute a disability under the Americans With Disabilities Act, if they are severe enough. The definition was made possible under 2009 amendments to the disability law that allowed for episodic impairments that substantially limit activity.


"By preventing people from eating, they are really preventing them from accessing their educational program," Hill says of the school and its students.


Mary Pat Lohse, the chief of staff and senior adviser to Lesley University's president, says the school has been working with the Justice Department for more than three years to address students' complaints. She says the school has already implemented most parts of the settlement and will continue to update policies to serve students who need gluten-free foods.


"The settlement agreement provides a positive road map for other colleges and universities to follow," Lohse says.


Joan Rector McGlockton of the National Restaurant Association says that restaurants have taken notice of an increasing demand for gluten free options, "drawing attention to the importance of providing these options as well as the preparation methods involved in serving these options."


The group has a training program for restaurants so they will know what to do when food allergy issues arise.


Some say the Justice Department decision goes too far. Hans von Spakovsky, a fellow at the conservative Heritage Foundation who worked in the civil rights division of the Justice Department under President George W. Bush, says food allergies shouldn't apply under the disability act. He adds that the costs could be substantial when schools are already battling backlash from high tuition costs.


"I certainly encourage colleges and universities to work with students on this issue, but the fact that this is a federal case and the Justice Department is going to be deciding what kind of meals could be served in a dining hall is just absurd," he says.


Whether the government is involved or not, schools and other food service establishments are likely to hear from those who want more gluten-free foods. Dhanu Thiyagarajan, a sophomore at the University of Pittsburgh, says she decided to speak up when she arrived at school and lost weight because there were too few gluten-free options available. Like Lesley University, the University of Pittsburgh requires that on-campus students participate in a meal plan.


Thiyagarajan eventually moved off campus so she could cook her own food, but not before starting an organization of students who suffer from wheat allergies like hers. She says she is now working with food service at the school and they have made a lot of progress, though not enough for her to move back on campus.


L. Scott Lissner, the disability coordinator at Ohio State University, says he has seen similar situations at his school, though people with food allergies have not traditionally thought of themselves as disabled. He says schools will eventually have to do more than just exempt students from a meal plan.


"This is an early decision on a growing wave of needs that universities are going to have to address," he says of the Lesley University agreement.


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Follow Mary Clare Jalonick on Twitter at http://twitter.com/mcjalonick


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Manti Te'o's Fake Girlfriend May Have Duped Others













Notre Dame star linebacker Manti Te'o's fake girlfriend "Lennay Kekua" may have hoaxed other unsuspecting suitors.


"Catfish" movie director and actor Ariel Schulman told "Good Morning America" today that he believes there may have been "a few other people duped by the fake Lennay character."


Schulman and his brother Nev Schulman have been looking into the elaborate scam and claim to be corresponding with various players involved. They have come to believe that there were "a lot of other people that she was corresponding with before and maybe even during her relationship [with Te'o]."


Nev Schulman was the subject of the 2010 movie "Catfish," which spawned the TV series, because he himself was sucked in by an Internet pretender -- or a "catfish" -- who built an elaborate fake life.


As questions mount about Te'o's possible role in the complex scam, the number one question is whether Te'o was unknowingly ensnared, as he says, or whether he was complicit in the scam.


"I stand by the guy. My heart goes out to him," Ariel Schulman said. His brother has reached out to Te'o, but has not heard back.


"He had his heart broken," Schulman said. "He was grieving for someone, whether she existed or not. Those were real feelings."






Streeter Lecka/Getty Images











Manti Te'o Hoax: Was He Duped or Did He Know? Watch Video









Manti Te'o Hoax: Notre Dame Star Allegedly Scammed Watch Video









Tale of Notre Dame Football Star's Girlfriend and Her Death an Alleged Hoax Watch Video





Click here for a who's who in the Manti Te'o case


Te'o has kept a low-profile since the news of the scandal broke. He released a statement calling the situation "incredibly embarrassing" and maintaining that he was a victim of the hoax.


He was captured briefly by news cameras on Thursday at a Florida training facility, but has not spoken publicly.


As for the woman whose photo was used as the face of Lennay Kekua, "Inside Edition" has identified her as Diane O'Meara who is very much alive. The show caught up with her on Thursday, but she declined to comment.


ABC News' legal analyst Dan Abrams said that O'Meara may be the one person in the scandal with the power to sue since her likeness was taken and used without her permission.


As for Te'o, even if he knew about the deception, it appears that he did not do anything illegal.


"He's allowed to lie to the public. He's allowed to lie to the media. He's not allowed to lie to the authorities," Abrams said on "Good Morning America."


Questions also remain about the timeline of events and when Te'o discovered that the "love of his life," as he called her, was nothing more than a fake Internet persona.


According to Notre Dame's timeline of events, Te'o learned his girlfriend didn't exist on Dec. 6.


But in a Dec. 8 interview with South Bend, Ind., TV station WSBT, Te'o said, "I really got hit with cancer. I lost both my grandparents an my girlfriend to cancer." And on Dec. 11, he talked about his girlfriend in a newspaper interview.


Te'o alerted Notre Dame on Dec. 26 about the scam, the university said.


Click here for more scandalous public confessions.


Skeptics have also cited comments by Te'o's father Brian Te'o who told a newspaper how Kekua used to visit his son in Hawaii.


Notre Dame athletic director Jack Swarbrick said the university launched their own investigation.


"Our investigators, through their work, were able to discover online chatter between the perpetrators," Swarbrick said at a Wednesday news conference. "That was sort of the ultimate proof."






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Four foreign hostages freed by Algerian army: APS


ALGIERS (Reuters) - Four foreign hostages were freed on Thursday by Algeria's armed forces, the official APS news agency said, giving no further details.


A local source has told Reuters six hostages were killed when a vehicle was fired upon by the military. A separate source, in the security services, said earlier that 25 foreigners had escaped. Gunmen said they were initially holding 41 foreign hostages after they stormed a gas plant in the remote Algerian desert on Wednesday morning. (Reporting by Lamine Chikhi; editing by Philippa Fletcher)



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Airbus lost top spot to Boeing in 2012






TOULOUSE, France - European group Airbus lost its top spot as the world's biggest maker of airliners to the US giant Boeing last year, but did better than expected and sees big sales this year, it said on Thursday.

Publishing results just as Boeing is hit by a crisis of confidence in its Dreamliner plane after a series of incidents, Airbus said that last year it delivered 588 aircraft to 89 customers, a record after 534 deliveries in 2011.

But sales of the flagship superjumbo A380, the biggest airliner in the world, disappointed, coming in at about one third of the target figure after a problem was discovered with the wings which the company says is now behind it.

Airbus sold a total of 833 aircraft last year, far more than the initial target figure of 650, chief executive Fabrice Bregier told a press conference near where Airbus is based at Toulouse, southern France.

However, the sales figure was far lower than the record of 1,419 sales in 2011.

Boeing delivered 601 airliners last year and took 1,203 orders.

For this year, Airbus expects to take 700 orders, excluding any cancellations, and to deliver more than 600 planes.

The order book now total 4,682 planes representing about eight years of production work.

Airbus said that it hoped that its new long-range A350 aircraft would make its maiden flight at the end of June or beginning of July.

Referring to the A350, Bregier said: "We have made reasonable good progress but I will keep cautious until the end.

"For the first flight, we expect it by mid of this year which is a big milestone, mid means end of June or early July...We are not optimistic nor pessimistic but realistic."

He added: "I'm very humble. Lots of risks are behind us but I'm interested in what is in front (of us)."

Of the 833 net orders last year, allowing for 81 cancellations, 739 were for medium-range A320-type airliners, popular with low-cost airlines, and of those 478 were for the "neo" version with new more fuel-efficient engines. The orders also comprised 58 long-haul A330 aircraft and 27 of the future A350.

Airbus booked orders for nine of its A380 superjumbo jetliners.

Bregier said that Airbus, the main part of the giant European EADS aerospace group, had exceeded its targets in terms of new orders booked and of completed aircraft delivered, even though sales of the superjumbo had underperformed.

Airbus had counted on selling 30 of the superjumbos but this target was knocked off course by the discovery of micro-cracks in the wings which cooled some customer interest.

Bregier said that this problem had been "resolved" and said he expected that this year the company would take 25 orders and would also deliver 25 of the enormous aircraft.

Referring to the position of Airbus in the global market and to the "neo" version, Bregier observed: "When we do better than expected we can be satisfied. When we see we are still in the leading position on neo market, we can be satisfied."

He said: "We started earlier with a good product. If we do the right job and I plan to do the right job, it's a huge advantage."

In view of the rapid growth, the airline has recruited a net number of 7,000 people in the last two years, hiring 10,000 while 3,000 have left for normal reasons.

The company cut 10,000 jobs between 2007 and 2009 as it restructured after a severe crisis over delays to the superjumbo programme which revealed weaknesses in the industrial workflow system.

The company now employs 59,000 people and expects to recruit 3,000 this year.

This is in contrast to many substantial employers in France which are restructuring with big job cuts, and the economy as a whole is struggling to boost its export performance and raise the niche speciality of its industrial products.

The Airbus aircraft are built mainly in Germany, Britain and Spain, and in France where they are assembled in Toulouse.

- AFP/ir



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India mulls huge increase in Rafale order, may buy up to 189 fighter jets

PARIS: India could buy up to 189 of the Rafale fighter jets currently being used by France to bomb Islamist militants in Mali, sources close to negotiations on the multi-billion dollar deal have told AFP.

The possibility of an additional 63 jets being added to an expected order for 126 was raised during a visit by India's foreign minister Salman Khurshid to Paris last week, they said.

"There is an option for procurement of an additional 63 aircrafts subsequently for which a separate contract would need to be signed," a source said.

"Presently the contract under negotiation is for 126 aircraft but we are talking about the follow-up."

India's contemplation of a much bigger than anticipated extension of its airpower will inevitably cause concern in neighbouring Pakistan given the permanently simmering tensions between the two countries.

The Indian press has estimated the value of the deal for 126 Rafales at $12 billion (nine billion euros).

A 50 per cent increase in the number of planes ordered would take it to around $18 billion, in a huge boost for the struggling French defence industry, although much of the economic benefit will be shared with India.

New Delhi selected France's Dassault Aviation as its preferred candidate to equip the Indian Air Force with new fighter jets in January 2012.

Under the deal on the table, the first 18 Rafales will be built in France but the next 108 will be assembled in India by Hindustan Aeronautics Ltd in Bangalore.

"The first aircraft will be delivered three years after signature of the contract," the source added.

An industry expert said the time lag reflected India's request for two-seater jets rather than the one-seater model that Dassault currently produces.

India has insisted that the deal involves significant technology transfer and that Indian suppliers secure work equivalent to around half of the value of the contract.

"The negociations for off-sets are progressing well," the source added.

The conclusion of the deal has been repeatedly delayed, with India having initially set a target of the end of last year, which slipped to March 31, 2013, the end of the current fiscal year.

French defence sources said last week that was unlikely to be met but voiced confidence it would finally be done, a stance echoed by Khurshid on his visit to Paris.

"We know good French wine takes time to mature and so do good contracts," Khurshid said after a meeting with French Foreign Minister Laurent Fabius.

"The contract details are being worked out. A decision has already been taken, just wait a little for the cork to pop and you'll have some good wine to taste."

Dassault and the French government are hoping that India's decision will have a positive influence on other potential buyers of the Rafale, who include Brazil, which is in the market for 36 planes, Canada, Malaysia and the United Arab Emirates.

The Rafale was used in a combat situation for the first time during the French-led Nato campaign which deposed Libyan dictator Moamer Kadhafi in 2011 and they have been active in Mali since the weekend.

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