Report: Tracking system needed to fight fake drugs

WASHINGTON (AP) — Fighting the problem of fake drugs will require putting medications through a chain of custody like U.S. courts require for evidence in a trial, the Institute of Medicine reported Wednesday.

The call for a national drug tracking system comes a week after the Food and Drug Administration warned doctors, for the third time in about a year, that it discovered a counterfeit batch of the cancer drug Avastin that lacked the real tumor-killing ingredient.

Fake and substandard drugs have become an increasing concern as U.S. pharmaceutical companies move more of their manufacturing overseas. The risk made headlines in 2008 when U.S. patients died from a contaminated blood thinner imported from China.

The Institute of Medicine report made clear that this is a global problem that requires an international response, with developing countries especially at risk from phony medications. Drug-resistant tuberculosis, for example, is fueled in part by watered-down medications sold in many poor countries.

"There can be nothing worse than for a patient to take a medication that either doesn't work or poisons the patient," said Lawrence O. Gostin, a professor of health law at Georgetown University who led the IOM committee that studied how to combat the growing problem.

A mandatory drug-tracking system could use some form of barcodes or electronic tags to verify that a medication and the ingredients used to make it are authentic at every step, from the manufacturing of the active ingredient all the way to the pharmacy, he said. His committee examined fakes so sophisticated that health experts couldn't tell the difference between the packaging of the FDA-approved product and the look-alike.

"It's unreliable unless you know where it's been and can secure each point in the supply chain," Gostin said.

Patient safety advocates have pushed for that kind of tracking system for years, but attempts to include it in FDA drug-safety legislation last summer failed.

The report also concluded that:

—The World Health Organization should develop an international code of practice that sets guidelines for monitoring, regulation and law enforcement to crack down on fake drugs.

—States should beef up licensing requirements for the wholesalers and distributors who get a drug from its manufacturer to the pharmacy, hospital or doctor's office.

__Internet pharmacies are a particularly weak link, because fraudulent sites can mimic legitimate ones. The report urged wider promotion of the National Association of Boards of Pharmacy's online accreditation program as a tool to help consumers spot trustworthy sites.

The Institute of Medicine is an independent organization that advises the government on health matters.

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Charred Human Remains Found in Burned Cabin

Investigators have located charred human remains in the burned-out cabin where they believe suspected cop killer and ex-LAPD officer Christopher Dorner was holed up as the structure burned to the ground, police said.

The human remains were found within the debris of the burned cabin and identification will be attempted through forensic means, the San Bernardino County Sheriff-Coroner Department said in a news release early this morning.

Dorner barricaded himself in the cabin in the San Bernardino Mountains near Big Bear Tuesday afternoon after engaging in a gunfight with police, killing one officer and injuring another, the San Bernardino County Sheriff's Department said.

Cindy Bachman, a spokeswoman for the department, which is the lead agency in the action, said Tuesday night investigators would remain at the site all night.

FULL COVERAGE: Christopher Dorner Manhunt

When Bachman was asked whether police thought Dorner was in the burning cabin, she said, "Right. We believe that the person that barricaded himself inside the cabin engaged in gunfire with our deputies and other law enforcement officers is still inside there, even though the building burned."

Bachman spoke shortly after the Los Angeles Police Department denied earlier reports that a body was found in the cabin, contradicting what law enforcement sources told ABC News and other news organizations.

Police around the cabin told ABC News they saw Dorner enter but never leave the building as it was consumed by flames, creating a billowing column of black smoke seen for miles.

A news conference is scheduled for later today in San Bernardino.

One sheriff's deputy was killed in a shootout with Dorner earlier Tuesday afternoon, believed to be his fourth victim after killing a Riverside police officer and two other people this month, including the daughter of a former police captain, and promising to kill many more in an online manifesto.

PHOTOS: Former LAPD Officer Suspected in Shootings

Carjacking Victim Says Christopher Dorner Was Dressed for Damage Watch Video

Christopher Dorner Manhunt: Inside the Shootout Watch Video

Chris Dorner Manhunt: Fugitive Ex-Cop in Shootout With Police Watch Video

Cops said they heard a single gunshot go off from inside the cabin just as they began to see smoke and fire. Later they heard the sound of more gunshots, which was the sound of ammunition being ignited by the heat of the blaze, law enforcement officials said.

Police did not enter the building, but shot tear gas inside.

One of the largest dragnets in recent history, which led police to follow clues across the West and into Mexico, apparently ended just miles from where Dorner's trail went cold last week.

It all began at 12:20 p.m. PT Tuesday, when a maid working at a local resort called 911, saying she and another worker had been tied up and held hostage by Dorner in a cabin, sources said.

The maid told police she was able to escape, but Dorner had stolen one of their cars, which was identified as a purple Nissan.

The San Bernardino Sheriff's Office and state Fish and Wildlife wardens spotted the stolen vehicle and engaged in a shootout with Dorner.

Officials say Dorner crashed the stolen vehicle and fled on foot only to commandeer Rick Heltebrake's white pickup truck on a nearby road a short time later.

"[Dorner] said, 'I don't want to hurt you, just get out and start walking up the road and take your dog with you.' He was calm. I was calm. I would say I was in fear for my life, there was no panic, he told me what to do and I did it," Heltebrake said.

"He was dressed in all camouflage, had a big assault sniper-type rifle. He had a vest on like a ballistic vest," Heltebrake added.

The white pickup truck bought Dorner extra time because police were still looking for the purple Nissan, California Department of Fish and Wildlife Lt. Patrick Foy told "Good Morning America" today.

"We were looking for a purple color Nissan and all of a sudden this white pickup starts coming by in the opposite direction. That's not the suspect's vehicle that we had been looking for," Foy said.

A warden with the Fish and Wildlife department noticed Dorner driving and the pursuit picked up again, Foy said.

"Ultimately, the officer who was driving that vehicle stopped and pulled out his patrol rifle and engaged probably 15 to 20 shots as Dorner was driving away," Foy said.

Dorner then ran on foot to the cabin in which he barricaded himself and got in a shootout with San Bernardino County sheriff's deputies and other officers who arrived.

The two deputies were wounded in the firefight and airlifted to a nearby hospital, where one died, police said. The second deputy was in surgery and was expected to survive, police said.

Police sealed all the roads into the area, preventing cars from entering the area and searching all of those on the way out. All schools were briefly placed on lockdown.

Believing that Dorner might have been watching reports of the standoff, authorities asked media not to broadcast images of police officers' surrounding the cabin, but sent him a message.

"If he's watching this, the message is: Enough is enough," Los Angeles Police Department spokesman Andy Smith told reporters at a news conference Tuesday. "It's time to turn yourself in. It's time to stop the bloodshed. It's time to let this event and let this incident be over."

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China joins U.S., Japan in condemning North Korea nuclear test

SEOUL (Reuters) - North Korea conducted its third nuclear test on Tuesday in defiance of existing U.N. resolutions, drawing condemnation from around the world, including from its only major ally, China, which summoned the North Korean ambassador to protest.

The reclusive North said the test was an act of self-defense against "U.S. hostility" and threatened further, stronger steps if necessary.

It said the test had "greater explosive force" than the 2006 and 2009 tests. Its KCNA news agency said it had used a "miniaturized" and lighter nuclear device, indicating that it had again used plutonium which is more suitable for use as a missile warhead.

North Korean leader Kim Jong-un, the third of his line to rule the country, has presided over two long-range rocket launches and a nuclear test during his first year in power, pursuing policies that have propelled his impoverished and malnourished country closer to becoming a nuclear weapons power.

China, which has shown signs of increasing exasperation with the recent bellicose tone of its neighbor, summoned the North Korean ambassador in Beijing and protested sternly, the Foreign Ministry said.

Foreign Minister Yang Jiechi said China was "strongly dissatisfied and resolutely opposed" to the test and urged North Korea to "stop any rhetoric or acts that could worsen situations and return to the right course of dialogue and consultation as soon as possible".

China is a permanent member of the Security Council.

U.S. President Barack Obama labeled the test a "highly provocative act" that hurt regional stability and pressed for new sanctions.

"The danger posed by North Korea's threatening activities warrants further swift and credible action by the international community. The United States will also continue to take steps necessary to defend ourselves and our allies," Obama said in a statement.

The Security Council will meet on Tuesday to discuss its reaction to the test, although North Korea is already one of the most heavily sanctioned states in the world and has few external economic links that can be targeted.

Japanese Prime Minister Shinzo Abe said the test was a "grave threat" that could not be tolerated. U.N. Secretary-General Ban Ki-moon said the test was a "clear and grave violation" of U.N. Security Council resolutions.

Russian Foreign Minister Sergei Lavrov urged North Korea to abandon its nuclear arms program and return to talks. NATO condemned the test as an "irresponsible act" that posed a grave threat to world peace.

The test "was only the first response we took with maximum restraint", an unnamed spokesman for the North Korean Foreign Ministry, which acts as Pyongyang's official voice to the outside world, said in a statement carried by the official KCNA news agency.

"If the United States continues to come out with hostility and complicates the situation, we will be forced to take stronger, second and third responses in consecutive steps."

North Korea often threatens the United States and its "puppet", South Korea, with destruction in colorful terms.

North Korea told the U.N. disarmament forum in Geneva that it would never bow to resolutions on its nuclear program and that prospects were "gloomy" for the denuclearization of the divided Korean peninsula because of a "hostile" U.S. policy.

South Korea, still technically at war with the North after the 1950-53 civil war ended in a mere truce, also denounced the test.

The magnitude was roughly twice as large as that of 2009, Lassina Zerbo, director of the international data centre division of the Vienna-based Comprehensive Nuclear-Test Ban Treaty Organization, said. The U.S. Geological Survey said that a seismic event measuring 5.1 magnitude had occurred.

"It was confirmed that the nuclear test that was carried out at a high level in a safe and perfect manner using a miniaturized and lighter nuclear device with greater explosive force than previously did not pose any negative impact on the surrounding ecological environment," KCNA said.

Despite China's strong response, the test is likely to be a major embarrassment for Beijing, the North's sole major economic and diplomatic ally.

"The test is hugely insulting to China, which now can be expected to follow through with threats to impose sanctions," said Mark Fitzpatrick of the International Institute for Strategic Studies think tank.

North Korea trumpeted the announcement on its state television channel to patriotic music against the backdrop of an image of its national flag.

It linked the test to its technical prowess in launching a long-range rocket in December, a move that triggered the U.N. sanctions, backed by China, that Pyongyang said prompted it to take Tuesday's action.

The North's ultimate aim, Washington believes, is to design an intercontinental ballistic missile capable of carrying a nuclear warhead that could hit the United States. North Korea says the program is aimed merely at putting satellites in space.

North Korea used plutonium in previous nuclear tests and prior to Tuesday there had been speculation it would use highly enriched uranium so as to conserve its plutonium stocks as testing eats into its limited supply of the material that could be used to construct a nuclear bomb.

"VICIOUS CYCLE"

Despite its three nuclear tests and long-range rocket tests, North Korea is not believed to be close to manufacturing a nuclear missile capable of hitting the United States.

South Korea's Yonhap news agency said Pyongyang had informed China and the United States of its plans to test on Monday, although this could not be confirmed.

When North Korean leader Kim, 30, took power after his father's death in December 2011, there were hopes the he would bring reforms and end Kim Jong-il's "military first" policies.

Instead, the North, whose economy is smaller than it was 20 years ago and where a third of children are believed to be malnourished, appears to be trapped in a cycle of sanctions followed by further provocations.

"The more North Korea shoots missiles, launches satellites or conducts nuclear tests, the more the U.N. Security Council will impose new and more severe sanctions," said Shen Dingli, a professor at Shanghai's Fudan University. "It is an endless, vicious cycle."

But options for the international community appear to be in short supply.

Tuesday's action appeared to have been timed for the run-up to February 16 anniversary celebrations of Kim Jong-il's birthday, as well as to achieved maximum international attention.

Significantly, the test comes at a time of political transition in China, Japan and South Korea, and as Obama begins his second term. He will likely have to tweak his State of the Union address due to be given on Tuesday.

Japanese Prime Minister Shinzo Abe is bedding down a new government and South Korea's new president, Park Geun-hye, prepares to take office on February 25.

China too is in the midst of a once-in-a-decade leadership transition to Xi Jinping, who takes office in March. Both Abe and Xi are staunch nationalists.

The longer-term game plan from Pyongyang may be to restart talks aimed at winning food and financial aid. China urged it to return to the stalled "six-party" talks on its nuclear program, hosted by China and including the two Koreas, the United States, Japan and Russia.

Its puny economy and small diplomatic reach mean the North struggles to win attention on the global stage - other than through nuclear tests and attacks on South Korea, last made in 2010.

"Now the next step for North Korea will be to offer talks... - any form to start up discussion again to bring things to their advantage," said Jeung Young-tae, senior research fellow at the Korea Institute for National Unification in Seoul.

The European Union's foreign policy chief, Catherine Ashton, urged North Korea to refrain from further provocation.

EU member Denmark called on China to step up to the plate and use its influence to rein in its ally.

"This deserves only one thing and that is a one-sided condemnation," said Foreign Minister Villy Sovndal. "North Korea is likely the most horrible country on this planet."

(Additional reporting by Jack Kim, Christine Kim and Jumin Park in SEOUL; Linda Sieg in TOKYO; Louis Charbonneau at the UNITED NATIONS; Fredrik Dahl in VIENNA; Michael Martina and Chen Aizhu in BEIJING; Mette Fraende in COPENHAGEN; Adrian Croft, Charlie Dunmore and Justyna Pawlak in BRUSSELS; Editing by Nick Macfie)

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Cycling: Sagan wins second stage in Oman, takes lead

AL BUSTAN, Oman: Slovakia's Peter Sagan won the second stage of the Tour of Oman on Tuesday and moved into the overall lead, following a 146km run from Fanja in Bidbid to Al Bustan, close to the Oman Sea.

The 23-year-old Cannondale rider broke free from the pack in the final kilometre to finish nine seconds in front of Frenchman Tony Gallopin, with Swiss rider Martin Elmiger a further two seconds back.

Sagan, the defending Slovakian champion, also won stage two on last year's race and counts three stages wins to his name on both the Tour de France and Tour of Spain in a career that continues to flourish.

Last year's Tour de France winner Bradley Wiggins endured a frustrating start to his challenge during stage one on Monday as he came in last over a minute behind stage winner Marcel Kittel.

The popular British rider was delayed by a pile-up in the last few kilometres of the 162km stage and came in 1min 30sec adrift of the leaders.

However, Team Sky are confident they will win an appeal on the basis that according to rules governing crashes, he should be awarded the same time as those riders he was riding within the closing 3km of a stage.

"There was a crash with 2km to go," said Team Sky's sports director Nicolas Portal.

"Bradley was not caught up in it but he was behind it and there was a little split in the peloton as the riders slowed down. So, with the 3km rule he should be fine."

The official results still listed the Olympic time-trial champion as 142nd and last before the start of stage two as Team Sky await a decision on their appeal.

The six-stage race continues on Wednesday with the third stage route over 190km between Nakhal Fort and Wadi Dayqah Dam, which features a profile that will again suit the likes of attacking riders like Sagan.

- AFP/al

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Newspapers in Kashmir to be available from Wednesday

SRINAGAR: Local newspapers in Kashmir would hit the stands Wednesday as their editors said authorities had told them to resume publication, while cable operations were again normal.

"We have been told to resume publications of our newspapers from tomorrow. Authorities have also said security forces have been instructed to treat identity cards of our staff members as curfew passes," the editor of a local newspaper told IANS.

Local newspaper editors had said they had to suspend publications Monday and Tuesday on the orders of the authorities.

Cable operators in Srinagar also said they have resumed operations after three days. They had Sunday stopped transmission under orders from the authorities.

Although there was no official confirmation of stop to cable operations and newspaper publication, senior police officers said the administration was worried about spread of rumours in the tension-ridden Valley after the Saturday execution of Parliament attack convict Afzal Guru.

In another development, police lodged an FIR against the security force unit whose personnel allegedly fired at protesters in north Kashmir's Watergam village Sunday leading to the death of a teenaged protestor.

Meanwhile, curfew continued without any relaxation in all the ten district headquarters of the valley for the fourth day on Tuesday.

Reports of sporadic clashes between protestors and security forces have come in from some places in the curfew-bound areas, but there has been no major incident of violence.

Three people have died so far during the protests in the valley after Guru's hanging.

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Pope shows lifetime jobs aren't always for life

The world seems surprised that an 85-year-old globe-trotting pope who just started tweeting wants to resign, but should it be? Maybe what should be surprising is that more leaders his age do not, considering the toll aging takes on bodies and minds amid a culture of constant communication and change.

There may be more behind the story of why Pope Benedict XVI decided to leave a job normally held for life. But the pontiff made it about age. He said the job called for "both strength of mind and body" and said his was deteriorating. He spoke of "today's world, subject to so many rapid changes," implying a difficulty keeping up despite his recent debut on Twitter.

"This seemed to me a very brave, courageous decision," especially because older people often don't recognize their own decline, said Dr. Seth Landefeld, an expert on aging and chairman of medicine at the University of Alabama at Birmingham.

Age has driven many leaders from jobs that used to be for life — Supreme Court justices, monarchs and other heads of state. As lifetimes expand, the woes of old age are catching up with more in seats of power. Some are choosing to step down rather than suffer long declines and disabilities as the pope's last predecessor did.

Since 1955, only one U.S. Supreme Court justice — Chief Justice William Rehnquist — has died in office. Twenty-one others chose to retire, the most recent being John Paul Stevens, who stepped down in 2010 at age 90.

When Thurgood Marshall stepped down in 1991 at the age of 82, citing health reasons, the Supreme Court justice's answer was blunt: "What's wrong with me? I'm old. I'm getting old and falling apart."

One in 5 U.S. senators is 70 or older, and some have retired rather than seek new terms, such as Hawaii's Daniel Akaka, who left office in January at age 88.

The Netherlands' Queen Beatrix, who just turned 75, recently said she will pass the crown to a son and put the country "in the hands of a new generation."

In Germany, where the pope was born, Chancellor Angela Merkel, who is 58, said the pope's decision that he was no longer fit for the job "earns my very highest respect."

"In our time of ever-lengthening life, many people will be able to understand how the pope as well has to deal with the burdens of aging," she told reporters in Berlin.

Experts on aging agreed.

"People's mental capacities in their 80s and 90s aren't what they were in their 40s and 50s. Their short-term memory is often not as good, their ability to think quickly on their feet, to execute decisions is often not as good," Landefeld said. Change is tougher to handle with age, and leaders like popes and presidents face "extraordinary demands that would tax anybody's physical and mental stamina."

Dr. Barbara Messinger-Rapport, geriatrics chief at the Cleveland Clinic, noted that half of people 85 and older in developed countries have some dementia, usually Alzheimer's. Even without such a disease, "it takes longer to make decisions, it takes longer to learn new things," she said.

But that's far from universal, said Dr. Thomas Perls, an expert on aging at Boston University and director of the New England Centenarians Study.

"Usually a man who is entirely healthy in his early 80s has demonstrated his survival prowess" and can live much longer, he said. People of privilege have better odds because they have access to good food and health care, and tend to lead clean lives.

"Even in the 1500s and 1600s there were popes in their 80s. It's remarkable. That would be today's centenarians," Perls said.

Arizona Sen. John McCain turned 71 while running for president in 2007. Had he won, he would have been the oldest person elected to a first term as president. Ronald Reagan was days away from turning 70 when he started his first term as president in 1981; he won re-election in 1984. Vice President Joe Biden just turned 70.

In the U.S. Senate, where seniority is rewarded and revered, South Carolina's Strom Thurmond didn't retire until age 100 in 2002. Sen. Robert Byrd of West Virginia was the longest-serving senator when he died in office at 92 in 2010.

Now the oldest U.S. senator is 89-year-old Frank Lautenberg of New Jersey. The oldest congressman is Ralph Hall of Texas who turns 90 in May.

The legendary Alan Greenspan was about to turn 80 when he retired as chairman of the Federal Reserve in 2006; he still works as a consultant.

Elsewhere around the world, Cuba's Fidel Castro — one of the world's longest serving heads of state — stepped down in 2006 at age 79 due to an intestinal illness that nearly killed him, handing power to his younger brother Raul. But the island is an example of aged leaders pushing on well into their dotage. Raul Castro now is 81 and his two top lieutenants are also octogenarians. Later this month, he is expected to be named to a new, five-year term as president.

Other leaders who are still working:

—England's Queen Elizabeth, 86.

—Abdullah bin Abd al-Aziz al-Saud, king of Saudi Arabia, 88.

—Sabah al-Ahmad al-Jaber al-Sabah, emir of Kuwait, 83.

—Ruth Bader Ginsburg, U.S. Supreme Court associate justice, 79.

__

Associated Press writers Paul Haven in Havana, Cuba; David Rising in Berlin; Seth Borenstein, Mark Sherman and Matt Yancey in Washington, and researcher Judy Ausuebel in New York contributed to this report.

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

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Could an African Cardinal Be the Next Pope?

Feb 12, 2013 9:09am

Ghanaian Cardinal Peter Kodwo Appiah Turkson attends a Mass for Pope John Paul II in St. Peter's Basilica at the Vatican, in this April 13, 2005 photo. (Pier Paolo Cito/AP Photo)

By BAZI KANANI and PHOEBE NATANSON

ROME – After Pope Benedict XVI became the first pope in hundreds of years to voluntarily resign, the Roman Catholic Church could be in for another first in recent history—an African pope.

Two African cardinals are rumored to be among the top candidates to succeed Pope Benedict, and many Vatican watchers believe the election of a non-European pope is a very real possibility at a time when the majority of the church’s growth is in the developing world.

Cardinal Peter Turkson, 64, of Ghana, is considered to be near the top of the short list of likely successors.  (British bookmakers offering odds on the next pope have already made Turkson their 3 to 1 favorite.)

After serving for more than 30 years as an ordained priest, Turkson was made a cardinal by Pope John Paul II in 2003.  He currently serves as president of the Vatican’s Council for Justice and Peace.  Colleagues describe him as a “people person” with excellent communication skills.  He is considered a conservative who is unlikely to steer the church in a new direction on issues such as contraception, abortion and gay rights.

Turkson outlined for ABC News Monday the challenge facing Benedict’s successor.

“The new pope has to be very sensitive to the present condition of humanity and yet recognize the task of having to still keep the Gospel in its pure form. That’s a big challenge that we all pray for,” he said.

“I think what we should be looking for, probably what we should be doing rather is recognizing the nature of the church… pray God will provide us with the leadership that can confidently lead the humanity in the church in the year ahead. The challenges are not going to cease. They’re going to be increasing and we need somebody with God’s guidance to get us through all this,” Turkson said.

Cardinal Francis Arinze, 80, of Nigeria is again being mentioned as a possible pope, as he was in 2005 when Pope Benedict was elected.  Arinze served as a priest for 27 years and became one of the world’s youngest bishops before Pope John Paul II elevated him to cardinal in 1985.

He was appointed to lead the Vatican’s Council for Interreligious Dialogue, and colleagues compliment his ability to cooperate with people of other faiths.  Arinze is also considered a conservative.

If the conclave of the College of Cardinals were to choose either Turkson or Arinze, it would be the first selection of an African pope in more than 1,500 years.  Scholars say in the first five centuries of the church there were three popes from North Africa. But the selection of Turkson or Arinze would be the first pope from sub-Saharan Africa and the first-ever black pope.

Vatican watchers also believe it is possible a Latin American pope could be selected.  The cardinals considered leading candidates from Latin America are said to be Leonardo Sandri from Argentina, Oscar Maradiaga from Honduras, Odilo Scherer from Brazil, and Joao Braz de Aviz from Brazil.

SHOWS: World News

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Pope Benedict stepping down, cites poor health

VATICAN CITY (Reuters) - Pope Benedict shocked the world on Monday by saying he no longer had the mental and physical strength to cope with his ministry, in an announcement that left his aides "incredulous" and will make him the first pontiff to step down since the Middle Ages.

The German-born Pope, 85, hailed as a hero by conservative Roman Catholics and viewed with suspicion by liberals, told cardinals in Latin that his strength had deteriorated recently. He will step down on February 28 and the Vatican expects a new Pope to be chosen by the end of March.

Vatican spokesman Father Federico Lombardi said the Pope had not decided to resign because of "difficulties in the papacy" and the move had been a surprise, indicating that even his inner circle was unaware that he was about to quit.

The Pope does not fear schism in the Church after his resignation, the spokesman said.

The Pope's leadership of 1.2 billion Catholics has been beset by child sexual abuse crises that tarnished the Church, one address in which he upset Muslims and a scandal over the leaking of his private papers by his personal butler.

The pope told the cardinals that in order to govern "...both strength of mind and body are necessary, strength which in the last few months, has deteriorated in me to the extent that I have had to recognize my incapacity to adequately fulfill the ministry entrusted to me.

"For this reason, and well aware of the seriousness of this act, with full freedom I declare that I renounce the ministry of Bishop of Rome, Successor of Saint Peter."

He also referred to "today's world, subject to so many rapid changes and shaken by questions of deep relevance for the life of faith."

The last Pope to resign willingly was Celestine V in 1294 after reigning for only five months, his resignation was known as "the great refusal" and was condemned by the poet Dante in the "Divine Comedy". Gregory XII reluctantly abdicated in 1415 to end a dispute with a rival claimant to the papacy.

"NO OUTSIDE PRESSURE," JUST ADVANCING AGE

Before he was elected Pope, the former Cardinal Joseph Ratzinger was known by such critical epithets as "God's rottweiler" because of his stern stand on theological issues.

But after several years into his new job Benedict showed that he not only did not bite but barely even barked.

In recent months, the pope has looked increasingly frail in public, sometimes being helped to walk by those around him.

Lombardi ruled out depression or uncertainty as being behind the resignation, saying the move was not due to any specific illness, just advancing age.

The Pope had shown "great courage, determination" aware of the "great problems the church faces today", he said, adding the timing may have reflected the Pope's desire to avoid the exhausting rush of Easter engagements.

There was no outside pressure and Benedict took his "personal decision" in the last few months, he added.

Israel's Chief Rabbi praised Benedict's inter-faith outreach and wished him good health. The Archbishop of Canterbury, head of the Anglican Church, said he had learned of the Pope's decision with a heavy heart but complete understanding.

German Chancellor Angela Merkel said the Pope's decision must be respected if he feels he is too weak to carry out his duties. British Prime Minister David Cameron said: "He will be missed as a spiritual leader to millions."

The pontiff would step down from 2 p.m. ET on February 28, leaving the office vacant until a successor was chosen to Benedict who succeeded John Paul, one of history's most popular pontiffs, the spokesman said.

Elected to the papacy on April 19, 2005 when he was 78 - 20 years older than John Paul was when he was elected - Benedict ruled over a slower-paced, more cerebral and less impulsive Vatican.

MEEK DEMEANOUR, STEELY INTELLECT

But while conservatives cheered him for trying to reaffirm traditional Catholic identity, his critics accused him of turning back the clock on reforms by nearly half a century and hurting dialogue with Muslims, Jews and other Christians.

Under the German's meek demeanor lay a steely intellect ready to dissect theological works for their dogmatic purity and debate fiercely against dissenters.

After appearing uncomfortable in the limelight at the start, he began feeling at home with his new job and showed that he intended to be Pope in his way.

Despite great reverence for his charismatic, globe-trotting predecessor -- whom he put on the fast track to sainthood and whom he beatified in 2011 -- aides said he was determined not to change his quiet manner to imitate John Paul's style.

A quiet, professorial type who relaxed by playing the piano, he managed to show the world the gentle side of the man who was the Vatican's chief doctrinal enforcer for nearly a quarter of a century.

The first German pope for some 1,000 years and the second non-Italian in a row, he traveled regularly, making about four foreign trips a year, but never managed to draw the oceanic crowds of his predecessor.

The child abuse scandals hounded most of his papacy. He ordered an official inquiry into abuse in Ireland, which led to the resignation of several bishops.

STRING OF SCANDALS

Scandal from a source much closer to home hit in 2012 when the pontiff's butler, responsible for dressing him and bringing him meals, was found to be the source of leaked documents alleging corruption in the Vatican's business dealings, causing an international furor.

He confronted his own country's past when he visited the Nazi death camp at Auschwitz.

Calling himself "a son of Germany", he prayed and asked why God was silent when 1.5 million victims, most of them Jews, died there during World War Two.

Ratzinger served in the Hitler Youth during World War Two when membership was compulsory. He was never a member of the Nazi party and his family opposed Adolf Hitler's regime.

But his trip to Germany also prompted the first major crisis of his pontificate. In a university lecture he quoted a 14th century Byzantine emperor as saying Islam had only brought evil to the world and that it was spread by the sword.

After protests that included attacks on churches in the Middle East and the killing of a nun in Somalia, the Pope later said he regretted any misunderstanding the speech caused.

In a move that was widely seen as conciliatory, in late 2006 he made a historic trip to predominantly Muslim Turkey and prayed in Istanbul's Blue Mosque with a Turkish Mufti.

But months later, former Iranian President Mohammad Khatami met the Pope and said wounds between Christians and Muslims were still "very deep" as a result of the Regensburg speech.

(Writing by Peter Millership; editing by Janet McBride and Ralph Boulton)

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Two Nobel Prize winners share their success stories

SINGAPORE: Fifteen internationally-renowned scientists were in Singapore recently for the inaugural Global Young Scientists Summit.

Among them were Nobel Prize winners Eric Cornell and Ada Yonath, who gave talks, participated in panel discussions and mentored young scientists during their time in Singapore.

The discoveries that garnered them the prestigious Nobel Prize were years in the making.

In 2009, Professor Yonath became the first woman in 45 years to win the Nobel Prize in Chemistry - after documenting the spatial structure of a ribosome, which are used by cells to make protein.

She said the discovery - the culmination of 20 years of research - was a dream come true.

"This was overwhelming, it is unbelievable, inside me I couldn't sleep, I saw it all the time," said Ms Yonath.

For Professor Cornell, who lost an arm to flesh-eating bacteria a few years ago, his discovery was the highlight of his career.

The physicist was one half of the duo that created a new form of matter - called a Bose-Einstein condensate, which had been predicted as early as the 1920s, but had never been proven up to that point.

Professor Cornell, who won the Nobel Prize in Physics in 2001, said: "It was exciting to win the Nobel Prize but not as exciting as it was to make the experiment work. It was 1995 when the experiment worked, I loved that! It was a sense of great power and excitement."

The loss of his left arm hasn't stopped him from going about his life and work as per normal. Professor Cornell said: "It wasn't very difficult to adapt...I am at a point in my career where I do not use my hands to adjust the apparatus.

"I have graduate students who are working, and I explain to them what to do, and they do it. So it hasn't changed my life very much. I have learnt how to type very rapidly with one hand..."

For both, science was a love affair that began when they were very young.

When she was five years old, Professor Yonath fell two floors trying to gauge the distance between the floor and the ceiling. She broke her hand in many places.

Meanwhile, Professor Cornell used to solve physics brainteasers when he had trouble falling asleep.

He said: "For me, I feel that learning physics is like discovering the secrets. You know maybe you are an actor, and performing in a play, and you get to go behind the scenes and see how the play comes together.

"I think as a physicist, it is like that. You get to go behind the scenes, find out what is really going on. I feel it is almost like secret knowledge."

And it is a love affair that has endured.

Professor Yonath said: "Once it becomes boring, I will stop. As long as it is interesting, my curiosity drives me. Passion for science and curiosity."

Both scientists said that summits which bring an international mix of young scientists together could pave the way for future collaborations.

- CNA/ms

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Afzal Guru's last letter to wife yet to reach her in Kashmir

NEW DELHI: Hours before he was to be executed, Afzal Guru penned his last letter to his wife, Tihar Jail officials said on Monday. The letter, written in Urdu, was posted on Saturday but is yet to reach his wife in Kashmir.

Speaking to IANS, officials at Tihar jail said that Afzal Guru, convicted for his role in the 2001 Parliament attack, was told on February 8 evening that he would be hanged the next morning.

"When he was told about his execution, he was cool and calm. He just expressed his wish that he wants to write a letter to his wife. The jail superintendent gave him a pen and paper," an official told IANS under condition of anonymity.

"He wrote the letter in Urdu, which was posted to his family in Kashmir on the same day," the official said. However, when IANS contacted the family, who live in Sopore, they said they are yet to receive it.

"We haven't received this letter. Maybe like the letter that we got today about his hanging, we will get it later," Yaseen Guru, Afzal's cousin, told IANS on phone.

Afzal Guru was hanged on February 9 at 8am in the Tihar Jail complex where he had lived in a solitary cell for many years.

His family has demanded that they be allowed to conduct his last rites.

"The government will take a decision in this regard," another official told IANS.

Afzal Guru, who used to spend his time in the jail by reading and writing, has left behind many books and hand-written articles.

The family has asked the jail authorities that all his belongings should be returned to them.

"The government will have to take a decision on this issue," the official added.

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